Coding combinatorial libraries with fluorine tags

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 1/04 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2305771

The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching "tags" that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead.

La présente invention concerne le codage de banques chimiques combinatoires synthétisées sur plusieurs supports solides par fixation de "marqueurs" comprenant des composés contenant du fluor dans des combinaisons et/ou des rapports. On peut décoder les marqueurs alors qu'ils sont fixés au support solide, par spectroscopie à résonance magnétique au fluor, pour tracer les antécédents réactionnels de perles individuelles et déterminer l'élément particulier de la banque qui est fixé à la perle.

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