Coding sequence polymorphisms in vascular pathology genes

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2324285

The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from the coding region of a gene, including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.

L'invention concerne des segments d'acides nucléiques du génome humain, en particulier des segments d'acides nucléiques provenant de la région de codage d'un gène qui comprend des sites polymorphes. L'invention concerne également des amorces et des sondes spécifiques d'allèle qui s'hybrident à des régions flanquant ou contenant ces sites. Les acides nucléiques, les amorces et les sondes sont utilisés dans des applications telles que des corrélations de phénotype, des examens médico-légaux, des tests de paternité, des analyses médicales et génétiques.

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