C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/35 (2006.01) C07K 14/435 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2411231
The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from Dermaphagoides dust mite. In particular, the optimised codon polynucleotides encode a protein from Dermaphagoides pteronyssinus, such as DerP1 or proDerP1. The present invention also provides methods of preparing pharmaceutical compositions comprising the expression of the codon optimised polynucleotides, and vectors and transformed host cells comprising them.
L'invention concerne des polynucléotides à codon optimisé qui sont exprimés de manière efficace dans des cellules mammaliennes et codent pour des protéines d'insecte provenant des acariens détriticoles Dermaphagoides. Les polynucléotides à codon optimisé codent notamment pour une protéine de Dermaphagoides pteronyssinus telle que DerP1 ou proDerP1. L'invention concerne aussi des procédés pour préparer des compositions pharmaceutiques comprenant l'expression des polynucléotides à codon optimisé ainsi que les vecteurs et cellules hôtes transformées les comprenant.
Bollen Alex
Jacobs Paul
Jacquet Alain
Massaer Marc Georges Francis
Glaxosmithkline Biologicals S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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