C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C12N 1/19 (2006.01) C12N 15/31 (2006.01) C12N 15/53 (2006.01) C12N 15/67 (2006.01) C12P 7/40 (2006.01) C12P 7/64 (2006.01)
Patent
CA 2522692
The present invention relates to fatty acid desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to .gamma.-linolenic acid (GLA); .alpha.-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-.gamma.- linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to ETA; eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA); and arachidonic acid (ARA) to EPA. Nucleic acid sequences encoding codon-optimized desaturases and elongases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the codon-optimized desaturase or elongases, and recombinant host microorganisms expressing increased levels of desaturase or elongase are described.
La présente invention concerne des désaturases et des élongases d'acides gras capables de catalyser la conversion d'acide linoléique (LA) en acide ?-linolénique (GLA), la conversion d'acide .alpha.-linoléique (ALA) en acide stéaridonique (STA), la conversion de GLA en acide dihomo-.gamma.-linoléique (DGLA); la conversion de STA en acide eicosatétraénoïque (ETA), la conversion de DGLA en ETA, la conversion d'acide eicosapentaénoïque (EPA) en acide docosapentaénoïque (DPA), et la conversion d'acide arachidonique (ARA) en EPA. L'invention concerne plus particulièrement des séquences d'acides nucléiques codant des désaturases et des élongases à condons optimisés, des séquences d'acides nucléiques qui s'hybrident avec les précédentes, des constructions d'ADN comprenant les désaturases et élongases à condons optimisés, et des micro-organismes hôtes recombinants qui expriment à des niveaux accrus la désaturase ou l'élongase.
Picataggio Stephen K.
Zhu Quinn Qun
Bennett Jones Llp
E.i. Du Pont de Nemours And Company
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