Codon-optimized papilloma virus sequences

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 39/12 (2006.01) C07K 14/025 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/67 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2416488

The present invention relates to methods and compositions useful in the treatment and prevention of human papilloma virus infections and the symptoms and diseases associated therewith. More particularly, the invention relates to polynucleotide sequences which encode human papilloma virus (HPV) amino acid amino acid sequences, wherein the codon usage pattern of the polynucleotide sequences resemble those of highly expressed mammalian genes.

L'invention concerne des procédés et des compositions efficaces en vue de traiter et prévenir les infections par le papillomavirus ainsi que les symptômes et affections associés à ce virus. L'invention concerne en particulier des séquences de polynucléotide qui codent les séquences aminoacide/aminoacide du papillomavirus (HPV), dans lesquelles le motif d'utilisation du codon des séquences de polynucléotide ressemble à ceux des gènes de mammifères présentant une expression élevée.

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