Coenzyme q10 compositions for organ protection during perfusion

Details Coenzyme q10 compositions for organ protection during perfusion Coenzyme q10 compositions for organ protection during perfusion

A - Human Necessities

01

N

A01N 1/02 (2006.01)

Patent

CA 2348636

The present invention describes compositions and methods for use when an organ is isolated from the circulatory system, i.e., in organ transplantation and surgery. The composition of the present invention uses an organ preservation or perfusion solution to which is added a Coenzyme Q10 in a solubilizing agent. The solubilizing agent of the present invention is capable of solubilizing Coenzyme Q10, is non-toxic to organ tissues and cells, and is compatible with organ perfusion devices. When used in an organ perfusion the compositions of the Coenzyme Q10 does not precipitate from the compositions of the present invention. Particularly, the solubilizing agents are polysorbates, such as polysorbate-80 (polyoxyethylene (20) sorbitan mono-oleate) or phosphatides, such as lecithin, and the like. Methods are also provided for using the compositions of the present invention to protect organs from free radical damage, ischemia and perfusion injury during organ transplant and surgery.

L'invention concerne des compositions et des procédés destinés à être utilisés lorsqu'un organe est isolé du système circulatoire, par exemple, en cas de transplantation d'organes et en chirurgie. La composition selon l'invention utilise une solution de conservation d'organes ou de perfusion, à laquelle on ajoute un coenzyme Q¿10? dans un agent de solubilisation. L'agent de solubilisation selon l'invention est capable de solubiliser le coenzyme Q¿10?, n'est pas toxique vis-à-vis des tissus et des cellules de l'organe, et est compatible avec les dispositifs de perfusion d'organes. Lorsqu'elle est utilisée dans une perfusion d'organes, la composition du coenzyme Q¿10? ne précipite pas à partir des compositions selon l'invention. En particulier, les agents de solubilisation sont des polysorbates, tels que polysorbate-80 (polyoxyéthylène (20) sorbitan mono-oléate) ou des phosphatides, tels que lécithine et analogues. Il est également spécifié des procédés pour l'utilisation des compositions selon l'invention, en vue de protéger des organes des dommages des radicaux libres, d'ischémie, des lésions due à une reperfusion en cours de chirurgie et de transplantation d'organes.

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