G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61P 43/00 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2390686
The invention relates to methods that enable identification of modulators of nuclear receptor (NR) activity and to methods for treating and/or preventing diseases or pathologic conditions associated with cell types that express said nuclear receptors. More particularly, the invention concerns to methods enabling the identification of compounds that induce or inhibit the recruitment of the p160 family cofactors, especially T1F-2 and/or SRCs cofactors and that are useful for modulating the PPAR-gamma biological activity and for treating and/or preventing various PPAR-gamma related diseases and conditions, including metabolic or cell proliferative disorders.
Auwerx Johan
Chambon Pierre
Picard Frederic
Institut National de La Sante Et de La Recherche Medicale
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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