Cohesive coprecipitates of sulfated polysaccharide and...

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01) A61K 9/50 (2006.01) A61K 9/64 (2006.01) A61L 31/10 (2006.01) C08L 5/02 (2006.01) C08L 89/06 (2006.01)

Patent

CA 2501009

The present invention concerns cohesive biopolymer gels comprising coprecipitates of sulfated polysaccharides and fibrillar proteins, exemplified by coprecipitates of dextran sulfate and gelatin, useful for clinical applications including as implants for tissue engineering as well as in biotechnology. The cohesive biopolymer gels according to the present invention may be used clinically either per se or as a scaffold for a cell-bearing implant, as a depot for sustained release of bioactive agents, or for research and biotechnology.

La présente invention concerne des gels biopolymères cohésifs renfermant des coprécipités de polysaccharides sulfatés et de protéines fibrillaires, par exemple, des coprécipités de sulfate de dextrane et de gélatine, utilisés dans des applications cliniques, telles que des implants pour le génie tissulaire, ainsi qu'en biotechnologie. Selon cette invention, ces gels biopolymères cohésifs peuvent être utilisés cliniquement soit per se soit comme échafaud d'implant de support cellulaire, comme dépôt pour la libération soutenue d'agents bio-actifs soit dans le domaine de la recherche et de la biotechnologie.

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