C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/16 (2006.01) A61K 31/16 (2006.01) A61K 31/225 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 219/26 (2006.01) C07C 235/74 (2006.01) C07D 211/62 (2006.01) C07D 295/14 (2006.01) C07D 295/18 (2006.01) C07D 295/185 (2006.01) C07D 295/215 (2006.01)
Patent
CA 2411160
The invention relates to colchinol derivatives of the formula 1: wherein the substituents are as defined in the description or a pharmaceutically- acceptable salt, solvate or pro-drug thereof. The invention also relates to processes for preparing compounds of formula (1), pharmaceutical compositions of compounds of formula (1) and the use of compounds of formula (1), in the manufacture of a medicament for use in the production of a vascular damaging effect in a warm blooded animal.
Cette invention concerne des dérivés de colchinol représentés par la formule (I) selon laquelle les substituants sont comme définis dans le descriptif ou sont constitués par un sel, un solvat ou un promédicament pharmaceutiquement acceptables desdits dérivés. L'invention concerne également des procédés de fabrication de composés selon la formule (1), des compositions pharmaceutiques renfermant les composés de formule (1) et l'utilisation desdits composés pour la fabrication d'un médicament provoquant une dégradation vasculaire chez un animal à sang chaud.
Arnould Jean Claude
Lamorlette Maryannick Andree
Angiogene Pharmaceuticals Limited
Fetherstonhaugh & Co.
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