Cold storage of modified platelets

Details Cold storage of modified platelets Cold storage of modified platelets

A - Human Necessities

01

N

A01N 1/02 (2006.01) A61K 35/14 (2006.01) A61P 7/00 (2006.01) C12N 5/02 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2637517

A method for storing and using platelets and an associated platelet structure. At least one modified platelet is formed. Each modified platelet includes a platelet and at least one polymerated chemical. Each polymerated chemical includes a polymer covalently bonded directly to the platelet or includes the polymer and a linker molecule such that the linker molecule is covalently bonded to the platelet and the polymer is covalently attached to the linker molecule. The polymer of each polymerated chemical of each modified platelet is polyethylene glycol (PEG) or a PEG derivative. Forming each modified platelet does not include modifying the platelet membrane of each platelet with a glycan-modifying agent. The at least one modified platelet is stored in a temperature range below 0°C. After being stored, the at least one modified platelet may be introduced into a subject to treat a condition related to a reduced platelet function

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