Collagen binding protein compositions and methods of use

Details Collagen binding protein compositions and methods of use Collagen binding protein compositions and methods of use

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61P 31/04 (2006.01) C07K 14/31 (2006.01) C07K 16/12 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2255669

Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aureus, and DNA segments encoding cna from related bacteria. Also disclosed are Col binding protein (CBP) compositions and methods of use. The CBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological infections, and in particular, for use in the prevention of bacterial adhesion to Col. DNA segments encoding these proteins and anti-(Col binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of bacterial colonization in an animal such as a human. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of S. aureus infection.

L'invention concerne le gène cna et des segments d'acide nucléique dérivés de cna provenant de Staphylococcus aureus, des segments d'ADN codant cna provenant de bactéries associées, ainsi que des compositions de protéine de liaison Col (PLC) et des procédés d'utilisation. La protéine PLC et les déterminants antigéniques dérivés de cette dernière sont utilisables dans le traitement des infections pathologiques et plus particulièrement pour la prophylaxie de l'adhésion bactérienne à Col. Des segments d'ADN codant ces protéines et des anti-anticorps anti-(protéine de liaison Col) sont également utiles dans diverses applications de recherche, de diagnostic et de thérapie comprenant l'immunisation active et passive et des procédés de prévention de colonisation bactérienne chez l'animal et l'homme. Ces segments d'ADN et les peptides dérivés de ces derniers sont utilisables dans la préparation de vaccins et, également comme protéines vecteurs dans des formulations de vaccins et dans la formulation de compositions destinées à être utilisées pour prévenir l'infection provoquée par S. aureus.

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