Collagen-binding synthetic peptidoglycans, preparation, and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/00 (2006.01) A61K 38/14 (2006.01) A61L 27/24 (2006.01) C07K 9/00 (2006.01) C08L 89/06 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2719254

This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

La présente invention concerne des peptidoglycanes synthétiques de liaison du collagène et des matrices de collagène modifiées comprenant une matrice de collagène et un peptidoglycane synthétique de liaison du collagène. Ledit peptidoglycane synthétique de liaison du collagène peut être aberrant ou présenter une homologie dacide aminé avec une partie de la séquence dacides aminés dune protéine ou un protéoglycane qui régule la fibrillogenèse du collagène. Linvention porte également sur des kits, des composés, des compositions, et des constructions de greffe modifiées comprenant de tels peptidoglycanes synthétiques de liaison du collagène ou des matrices de collagène modifiées. Enfin, linvention concerne des procédés permettant de les préparer et de les utiliser.

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