C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/323, 167/103
C12N 9/96 (2006.01) A61K 9/20 (2006.01) A61K 47/42 (2006.01) A61L 15/38 (2006.01) A61L 17/08 (2006.01) A61L 27/24 (2006.01) C12N 11/02 (2006.01) A61F 2/00 (2006.01)
Patent
CA 1186625
ABSTRACT OF THE DISCLOSURE Collagen polymers are rendered non-inflammatory by complexation with alkaline phosphatase according to the procedure disclosed. Applications of these non-inflammatory collagen complexes include the production of non-inflamma- tory collagen sutures, collagen soft tissue replacements including wound and burn coverings and arterial vessel replacements, collagen drug delivery devices, and vitreous replacement for opthalmologic therapy. Gels composed of the collagen-alkaline phosphatase conjugate plus calcium hydroxide are useful as an agent in endodontic therapy. Structural durability and stabilization of the anti- inflammatory properties of the material are enhanced by crosslinking with glutaraldehyde or other crosslinking agents. Glutaraldehyde also acts to sterilize and disinfect the collagen conjugate prior to in-vivo use.
419233
Gowling Lafleur Henderson Llp
Jefferies Steven R.
LandOfFree
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