Collagen-like polymers with cell binding activity

Details Collagen-like polymers with cell binding activity Collagen-like polymers with cell binding activity

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61L 27/22 (2006.01) A61L 27/34 (2006.01) A61L 31/04 (2006.01) A61L 31/10 (2006.01)

Patent

CA 2286687

The invention is essentially directed to a biocompatible material comprising a bulk material which has covalently bound to a surface or surfaces thereof one or more biopolymer compounds, said biopolymer compounds comprising at least one peptoid residue. The biopolymer compounds are most preferably polymer compounds comprising the sequence of the formula (I): -(Gly-Pro-Nleu)(Y)-, wherein (y) denotes 9. Also disclosed is a method of binding biopolymer compounds to a bulk material, which biopolymer compounds comprise at least one peptoid residue, as well as primary amine groups, the method comprising the steps of: (a) providing aldehyde or carboxyl groups on a surface or surfaces of said bulk material; (b) reacting said primary amine groups with aldehyde or carboxyl groups to form covalent bonds.

L'invention concerne essentiellement une matière biocompatible comprenant une matière en vrac qui a lié par covalence à une ou plusieurs de ses surfaces un ou plusieurs composés biopolymères, lesdits composés biopolymères comprenant au moins un reste peptoïde. Les composés biopolymères sont de préférence des composés polymères comprenant la séquence de la formule (I): -(Gly-Pro-Nleu)¿(y)?-, dans laquelle (y) à la signification ? 9. Un procédé de liaison de composés biopolymères à une matière en vrac fait aussi l'objet de cette invention. Lesdits composés biopolymères comprennent au moins un reste peptoïde, ainsi que des groupes amino primaires. Le procédé consiste (a) à placer des groupes aldéhyde ou carboxyle sur une ou plusieurs surfaces de ladite matière en vrac; (b) à faire réagir lesdits groupes amino primaires avec des groupes aldéhyde ou carboxyle pour former des liaisons covalentes.

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