Collagen mimics

Details Collagen mimics Collagen mimics

C - Chemistry, Metallurgy

07

K

C07K 14/78 (2006.01) A61K 38/39 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2301175

A novel collagen mimic comprising a tripeptide unit having the formula (XaaFlpGly)n, where Flp is 4(R)-fluoro-L-proline, is disclosed. The collagen mimic has increased stability relative to the collagen- related triple helices (ProProGly)n and (ProHypGly)n.

L'invention porte sur un nouvel analogue du collagène qui comprend une unité tripeptidique ayant la formule(XaaFlpGly)n, dans laquelle Flp représente 4(R)-fluoro-L-proline. L'analogue du collagène présente une meilleure stabilité par rapport aux triples hélices relatives au collagène (ProProGly)n et (ProHypGly)n.

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