C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/78 (2006.01) C07K 17/00 (2006.01) C12N 5/20 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2297555
The invention includes a method of determining the level of Type I collagen fragments in a biological fluid using an antibody which is immunospecific for an epitope contained in one of the following sequences: (1) Ala-Hyp-Gly-Asp- Arg-Gly-Glu-Hyp-Gly-Pro-Hyp-Gly-Pro-Ala, or (2) Gly-Asn-Ser-Gly-Glu-Hyp-Gly- Ala-Hyp, under conditions effective to allow determination of the level of collagen fragments in the sample which contain the epitope. The method is useful for assessing the level of bone collagen degradation, particularly in humans. Also disclosed are antibodies and kits which can be used in the method.
L'invention concerne un procédé pour déterminer la teneur en fragments de collagène de type I d'un fluide biologique, à l'aide d'un anticorps qui est immunospécifique pour un épitope renfermé dans l'une des séquences suivantes: (1) Ala-Hyp-Gly-Asp-Arg-Gly-Glu-Hyp-Gly-Pro-Hyp-Gly-Pro-Ala, ou (2) Gly-Asn-Ser-Gly-Glu-Hyp-Gly-Ala-Hyp. Ce procédé est mis en oeuvre dans des conditions permettant de déterminer la teneur en fragments de collagène dans l'échantillon contenant l'épitope. Ce procédé permet d'évaluer le niveau de dégradation du collagène osseux, en particulier, chez l'homme. L'invention traite d'anticorps et de kits pouvant être utilisés avec ce procédé.
Byrne Michael H.
Ju Hsin-Shan J.
Krane Stephen M.
Leigh Scott D.
Gowling Lafleur Henderson Llp
Metra Biosystems Inc.
The General Hospital Corporation
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