Collagen peptides and uses thereof

Details Collagen peptides and uses thereof Collagen peptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/78 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2325017

Collagen peptides, fragments and variants are able to interact with and/or bind integrin .alpha.2.beta.1, integrin .alpha.1.beta.1 and/or platelet receptor GpVI. Such peptides, mimetics thereof and substances that bind them are useful in modulating platelet and other cell function, including aggregation and activation.

L'invention concerne des peptides, des fragments et des variantes de collagène capables d'interagir et/ou de se lier avec l'intégrine .alpha.2.beta.1, l'intégrine .alpha.1.beta.1, et/ou le récepteur GpVI des plaquettes. Ces peptides, des mimétiques de ces peptides et des substances liant ces peptides sont utiles dans la modulation plaquettaire et autres fonctions cellulaires, notamment l'agrégation et l'activation.

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