Collagen-related peptides and uses thereof and hemostatic...

A - Human Necessities – 61 – L

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A61L 15/26 (2006.01) A61L 15/32 (2006.01) A61L 15/42 (2006.01)

Patent

CA 2751132

The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and compositions thereof. The present invention also relates to novel hemostatic foam substrates, a method of manufacturing the foam substrates, and a method of stimulating hemostasis in a mammal using such foam substrates.

La présente invention concerne un polypeptide lié au collagène (CRP) présentant des groupes d'acides aminés hydrophobes aux extrémités N- et C-terminales pouvant s'auto-assembler de manière non covalente en triples hélices mimétiques du collagène et en fibrilles de celui-ci, ainsi que la synthèse, des procédés d'utilisation et des compositions associés. La présente invention concerne également de nouveaux substrats en mousse hémostatiques, un procédé de fabrication des substrats en mousse, et un procédé permettant de stimuler l'hémostase chez un mammifère à l'aide de tels substrats en mousse.

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