Collagen type i and type iii adhesive compositions

C - Chemistry – Metallurgy – 08 – F

Patent

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Details

C08F 2/46 (2006.01) A61L 24/10 (2006.01) C08F 2/48 (2006.01) C08H 1/00 (2006.01) C08J 3/28 (2006.01) C08L 89/00 (2006.01) C08L 89/06 (2006.01) C09J 189/06 (2006.01)

Patent

CA 2308146

Polymerized type I and/or III collagen based compositions for medical use as adhesives and sealants and preparation thereof are described. Prior to polymerization, the collagen monomers are prepared recombinantly whereby chemical modifications of the collagen are not needed to form such monomers. The type I and/or III collagen compositions are useful as medical adhesives for bonding soft tissues or in a sealant film for a variety of medical uses. In a further aspect of the present invention, the polymerized type I and/or III collagen composition includes agents which induce wound healing or provide for additional beneficial characteristics desired in a tissue adhesive and sealant.

On décrit des compositions à base de collagène polymérisé du type I et/ou du type III destinées à un usage médical en tant qu'adhésif et que matériau d'étanchéité ainsi que la préparation de ces compositions. Avant la polymérisation, les monomères de collagène sont préparés par recombinaison étant donné que les modifications chimiques du collagène ne sont pas nécessaires pour former ces monomères. Des compositions de collagène du type I et/ou du type III sont utiles en tant qu'adhésif utilisé en médecine pour souder des tissus mous ou dans un film d'étanchéité destiné à diverses utilisations en médecine. Dans un autre aspect de cette invention, la composition de collagène polymérisé du type I et/ou du type III comprend des agents qui induisent la cicatrisation ou apporte des caractéristiques intéressantes supplémentaires désirées pour un adhésif destiné à des tissus et un produit assurant l'étanchéité.

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