Collagen type i and type iii hemostatic compositions for use...

A - Human Necessities – 61 – L

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A61L 24/10 (2006.01) A61K 38/39 (2006.01) A61L 15/32 (2006.01) A61L 24/04 (2006.01) C07K 14/78 (2006.01) A61B 17/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2339575

Polymerized type I and/or III collagen based compositions for medical use as vascular sealants and wound dressings, and the preparation thereof, are described. Prior to polymerization, the collagen monomers are prepared recombinantly whereby chemical modifications of the collagen are not needed to form such monomers. The type I and/or III collagen compositions, which include gelatin comprised of type I and type III collagens, are useful as medical adhesives for bonding soft tissues and as sealants for a variety of medical uses. In a further aspect of the present invention, the polymerized type I and/or III collagen compositions include agents which induce wound healing or provide for additional beneficial characteristics desired in a tissue sealant or wound dressing. The compositions of the present invention are also useful in non-adhesive form.

L'invention concerne des compositions à base de collagène de type I et/ou de type III polymérisé, à usage médical sous forme de produits de scellement vasculaire et de pansements, et la préparation desdites compositions. Avant la polymérisation, des monomères de collagène sont préparés par recombinaison, des modifications chimiques du collagène n'étant pas nécessaires pour la formation desdits monomères. Les compositions à base de collagène de type I et/ou III, comprennent une gélatine constituée de collagènes de type I et III, et sont utiles en tant qu'adhésifs médicaux pour la liaison de tissus mous et comme produit de scellement pour une grande variété d'usages médicaux. Selon un autre aspect de l'invention, les compositions à base de collagène de type I et/ou III polymérisé, comprennent des agents induisant la cicatrisation ou conférant les caractéristiques supplémentaires bénéfiques voulues à un produit de scellement de tissus ou à un pansement. Les compositions de l'invention sont également utiles sous forme non adhésive.

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