Collagenase inhibitor

Details Collagenase inhibitor Collagenase inhibitor

C - Chemistry, Metallurgy

07

D

C07D 237/04 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2123104

ABSTRACT OF THE DISCLOSURE Constitution: a novel compound represented by general formula (I), wherein R1 represents -OR3(R3 being H or alkyl), -NR4R5(R4 and R5 being each H, alkyl or alkoxy), -NHCH(R6)COR7 (R6 being H or alkyl, and R7 being alkyl), -NHCH(R6)COOR8(R8 being alkyl) or -NHCH(R6)CONR9R10(R9 and R10 being each H or alkyl, or alternatively NR9R10 being a heterocyclic group as a whole); and R2 represents H, alkyl or aralkyl. Effect: since the compound has an inhibitory activity type IV collagenase, it is useful as an inhibitor against vascularization, cancer infiltration or cancer metastasis.

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