Collagenous tissue compositions

Details Collagenous tissue compositions Collagenous tissue compositions

A - Human Necessities

61

L

A61L 27/36 (2006.01) A61L 27/26 (2006.01)

Patent

CA 2343806

Implant compositions are disclosed consisting of a biocompatible carrier medium such as a saline or dextran solution and particles of collagenous material dispersed therein. The collagenous material is derived from tissue which has been milled to provide fragments of collagen fibres which preserve the architecture of the original fibres and their molecular structure. The collagenous material is also substantially free of non-fibrous tissue proteins, glycoproteins, cellular elements and lipids or lipid residues, and is non-cytotoxic. By suitable choice of particle size and concentration, the composition may be presented in injectable form or as a paste. The compositions are suitable for application in cosmetic and reconstruction surgery.

On décrit des compositions d'implant constituées d'un milieu de support biocompatible tel qu'une solution saline ou de dextrane et de particules de matière collagène dispersées dans ladite solution. La matière collagène provient d'un tissu qui a été broyé pour produire des fibres de collagène qui conservent l'architecture des fibres de départ et leur structure moléculaire. La matière collagène est en outre sensiblement dépourvue de protéines de tissus non fibreux, de glycoprotéines, d'éléments cellulaires et de lipides ou de restes de lipides, et non toxique. Le fait de sélectionner une grosseur particulaire et une concentration adaptées permet de présenter la composition sous une forme injectable ou sous forme de pâte. Les compositions sont adaptées pour être utilisées en chirurgie esthétique et en chirurgie réparatrice.

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