Collections of compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/04 (2006.01) A61K 31/5517 (2006.01) C07B 61/00 (2006.01) C07D 209/00 (2006.01) C07D 243/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2341386

A compound of formula (I), wherein: R2 and R3 are independently selected from H, R, OH, OR, =0, =CH-R, =CH2, CH2-CO2R, CH2-CO2H, CH2-SO2R, O-SO2R, CO2R, COR and CN, and there is optionally a double bond between C1 and C2 or C2 and C3; R6, R7, R8 and R9 are independently selected from H, R, OH, OR, halo, nitro, amino, Me3Sn; R11 is either H or R; Q is S, O or NH; L is a linking group, or a single bond; O is a solid support; or where one or more of R2, R3, R6, R7 and R8 are independently: H-(T)n-X-Y-A- where: X is CO, NH, S or O; T is a combinatorial unit; Y is a divalent group such that HY = R; A is O, S, NH, or a single bond and n is a positive integer.

L'invention concerne un composé selon la formule (I). Dans cette dernière, R¿2? et R¿3? sont indépendamment sélectionnés parmi H, R, OH, OR, =O, =CH-R, =CH¿2?, CH¿2?-CO¿2?R, CH¿2?-CO¿2?H, CH¿2?-SO¿2?R, O-SO¿2?R, CO¿2?R, COR et CN, et il existe éventuellement une double liaison entre C1 et C2 ou C2 et C3; R¿6?, R¿7?, R¿8? et R¿9? sont indépendamment sélectionnés parmi H, R, OH, OR, halo, nitro, amino et Me¿3?Sn; R¿11? est H ou R; Q représente S, O ou NH; L représente un groupe de liaison ou une simple liaison; O est un support solide ou bien dans la formule un ou plusieurs éléments parmi R¿2?, R¿3?, R¿6?, R¿7? et R¿8? sont indépendamment H-(T)¿n?-X'-Y-A- où X' représente CO, NH, S ou O; T est une unité combinatoire, Y est un groupe divalent tel que HY = R; A représente O, S, NH ou une simple liaison et n est un nombre entier positif.

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