A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01) A61K 9/107 (2006.01)
Patent
CA 2442532
The invention concerns an aqueous suspension, stable in physiological medium, of nanoparticles for delivering active principles for example insulin. Said delivering particles are based on a three-block copolymer: polyethylene glycol/hydrophilic polyaminoacid/hydrophobic polyaminoacid. Said three-block copolymer particles can be associated with an active principle without denaturing it, and perform a controlled and long-term release of said active principle in vivo, thereby providing the active principle with very prolonged release. The invention also concerns the powder-form solid from which are derived the delivering particles and the preparation of said powder-form solid and said suspension of delivering particles based on three-block copolymer. The invention further concerns pharmaceutical specialities obtainable from said delivering particles filled with active principle.
L'invention concerne une suspension aqueuse, stable en milieu physiologique, de nanoparticules de vectorisation PV de principes actifs PA (par ex.insuline). Ces PV sont à base d'un copolymère tribloc: PolyEthylène- Glycol/polyaminoacide hydrophile/ polyaminoacide hydrophobe. Ces particules de copolymère tribloc peuvent s'associer à un PA sans le dénaturer, puis relarguer ce PA in vivo de façon contrôlée et pendant une très longue durée. Cela assure donc au PA une durée d'action très prolongée.L'invention vise, également, le solide pulvérulent à partir duquel sont issues les PV ainsi que la préparation de ce solide pulvérulent et de cette suspension de PV à base de copolymère tribloc. L'invention concerne les spécialités pharmaceutiques suscepti-bles d'être obtenues à partir de ces particules de vectori-sation chargées en principe actif.
Bryson Nathan
Soula Gerard
Flamel Technologies
Robic
LandOfFree
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