Colon cancer associated transcript 1 (ccat-1) as a cancer...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2715170

The present invention relates to the identification, isolation, and sequencing of a unique nucleic acid transcript termed Colon Cancer Associated Transcript 1 (CCAT-1) that is specifically expressed in cancer cells, in particular in colon, rectal, and lung cancer, as well as in precancerous lesions. The present invention thus provides methods for diagnosing cancer by detect-ing the expression of CCAT-1 as well as isolated polynucleotides, compositions and kits for use in the detection methods of the invention.

La présente invention porte sur l'identification, l'isolement et le séquençage d'un produit de transcription d'acide nucléique unique appelé transcript 1 associé au cancer du côlon (CCAT-1) qui est spécifiquement exprimé dans des cellules cancéreuses, en particulier dans le cancer du côlon, le cancer rectal et le cancer des poumons, ainsi que dans des lésions précancéreuses. La présente invention fournit ainsi des procédés pour diagnostiquer un cancer par la détection de l'expression de CCAT-1 ainsi que sur des polynucléotides isolés, sur des compositions et sur des trousses pour une utilisation dans les procédés de détection de l'invention.

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