Colon cancer marker

Details Colon cancer marker Colon cancer marker

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2430762

The invention provides a cDNA which encodes a colon cancer marker. It also provides for the use of the cDNA, fragments, complements, and variants thereof and the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of colon disorders, particularly colon cancer and polyps. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

L'invention se rapporte à un ADNc qui code un marqueur du cancer du colon. Elle se rapporte également à l'utilisation de cet ADNc, de fragments, de compléments et de variants de cette ADNc ainsi qu'à la protéine codée, à des parties de cette protéine et à des anticorps dirigés contre cet ADNc pour le diagnostic et le traitement de troubles du colon, notamment le cancer du colon et les polypes. L'invention se rapporte en outre à des vecteurs d'expression et à des cellules hôtes pour la production de ladite protéine et d'un système de modèle transgénique.

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