Colon specific gene and protein

Details Colon specific gene and protein Colon specific gene and protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2221795

Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.

L'invention concerne des polypeptides de gènes spécifiques du colon humain et l'ADN (RNA) codant ces polypeptides, ainsi qu'une procédure de production desdits polypeptides par des techniques de recombinaison. L'invention concerne également des procédés d'utilisation de ces polynucléotides ou polypeptides comme marqueurs de diagnostic dans le cas du cancer du colon, et en tant qu'agent permettant de déterminer si le cancer du colon est métastasé. L'invention concerne également des anticorps spécifiques des polypeptides des gènes spécifiques du colon, qui peuvent être utilisés pour cibler des cellules cancéreuses, ou comme composants d'un vaccin contre le cancer du colon. L'invention concerne en outre des procédés de criblage d'agonistes et d'antagonistes aux polypeptides, ainsi que des utilisations thérapeutiques des antagonistes.

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