Colonic delivery of nicotine to treat inflammatory bowel...

Details Colonic delivery of nicotine to treat inflammatory bowel... Colonic delivery of nicotine to treat inflammatory bowel...

A - Human Necessities

61

K

A61K 31/465 (2006.01) A61K 9/00 (2006.01) A61K 9/22 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2246235

A method is provided to treat inflammatory bowel disease by locally administering to the colon an effective amount of nicotine or a pharamaceutically acceptable salt thereof, preferably via formulations adapted for delayed oral release or rectal administration. Further provided is a novel formulation for the oral administration of nicotine comprising a polyacrylic polymer complexed with nicotine.

L'invention concerne un procédé de traitement des maladies intestinales inflammatoires qui consiste à administrer localement dans le côlon une quantité efficace de nicotine ou d'un sel pharmaceutiquement acceptable de celle-ci, de préférence par l'intermédiaire de formulations conçues pour l'administration orale ou rectale à libération prolongée. L'invention concerne également une nouvelle formulation utilisée dans l'administration orale de nicotine et comprenant un polymère polyacrylique complexé avec la nicotine.

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