A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 9/22 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01)
Patent
CA 2264637
There is provided a controlled release formulation including an inner core comprising, or coated with, a drug, which drug possesses (a) a free acid group which can be converted into an alkali metal salt and (b) a pKa in the range 2.0 to 9.0, which inner core is subsequently coated with a rate-controlling membrane that determines drug release, wherein the drug is present as a salt that displays higher solubility at pH 4.5 to 8.0 than the corresponding compound containing a free acid group.
Formulation à libération régulée comprenant un noyau interne qui contient un médicament ou qui est enrobé d'un médicament qui lui-même possède (a) un groupe acide libre pouvant être transformé en un sel de métal alcalin et (b) un pKa situé dans la plage 2,0-9,0, ledit noyau interne étant ensuite enrobé d'une membrane régulant le débit qui détermine la libération du médicament. Le médicament est présent sous forme d'un sel qui présente, à un pH compris entre 4,5 et 8,0, une solubilité supérieure à celle du composé correspondant contenant un groupe acide libre.
Danbiosyst Uk Limited
Russell Reyneke
West Pharmaceutical Services Drug Delivery & Clinical Research C
LandOfFree
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