Colonic drug delivery formulation

Details Colonic drug delivery formulation Colonic drug delivery formulation

A - Human Necessities

61

K

A61K 9/28 (2006.01)

Patent

CA 2648658

A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.

L'invention concerne un enrobage à libération retardée comprenant un mélange d'une première matière choisie parmi l'amidon, l'amylose, l'amylopectine, le chitosane, le sulfate de chondroïtine, la cyclodextrine, le dextrane, le pullulane, le carraghénane, le scléroglucane, la chitine, le curdulane et le levane, et d'une seconde matière présentant un seuil de pH supérieur ou égal à environ 5. Cet enrobage est utilisé pour cibler la libération d'un médicament à partir d'un noyau sur l'intestin, et notamment sur le côlon.

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