Colonic-targeted oral drug-dosage forms based on crosslinked...

Details Colonic-targeted oral drug-dosage forms based on crosslinked... Colonic-targeted oral drug-dosage forms based on crosslinked...

C - Chemistry, Metallurgy

08

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C08L 57/06 (2006.01) A61K 9/20 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) C08F 246/00 (2006.01)

Patent

CA 2080224

2080224 9116057 PCTABS00007 Colonic-targeted oral drug dosage forms composed of a drug confined within a crosslinked hydrogel that exhibits pH-dependent swelling and is composed of an ionizable comonomer such as acrylic acid, a nonionizable comonomer such as an acrylamide, and a crosslinking agent that contains an aromatic azobond. Selective drug release in the colon occurs by a combination of pH-dependent swelling of the hydrogel and degradation of the hydrogel by enzymatic cleavage of the azobonds by azoreductases.

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