Color-stable, low impurity tocopherol compositions and...

Details Color-stable, low impurity tocopherol compositions and... Color-stable, low impurity tocopherol compositions and...

C - Chemistry, Metallurgy

07

D

C07D 311/72 (2006.01) A61K 31/355 (2006.01) C07D 311/78 (2006.01)

Patent

CA 2492831

Processes for preparing color-stable, low impurity tocopherol compositions are described, wherein the processes comprise: (a) providing a protecting group- substituted tocopherol compound, for example an acetate of a natural-source tocopherol compound; (b) purfying the protecting group-substituted tocopherol compound, for example through crystallization; and (c) solvolyzing the purified compound to form free tocopherol. Also described are the tocopherol compositions prepared thereby.

Procédés de préparation de compositions de tocophérol de couleur stable et comportant peu d'impuretés. Ces procédés comprennent les étapes consistant à : (a) prévoir un composé de tocophérol à groupe de protection substitué, par exemple un acétate d'un composé de tocophérol d'origine naturelle ; (b) purifier ledit composé, par exemple par cristallisation ; et (c) soumettre le composé purifié à une solvolyse pour former un tocophérol libre. L'invention concerne aussi des compositions de tocophérol préparées selon ces procédés.

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