Colored gelatin-based formulations and method

A - Human Necessities – 61 – K

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A61K 9/48 (2006.01) C08J 3/24 (2006.01) C08L 89/06 (2006.01)

Patent

CA 2426786

The present invention is a process for coloring gelatin-based formulations involving adding a saturated fatty acid to the gelatin-based formulation along with lake pigment, whereby the saturated fatty acid is added in an amount so as to prevent cross-linking between the gelatin-based formulations and the aluminum cations released by the lake pigments. Preferably, this amount is about 10 % to about 300 % by weight of the added lake pigment content. With this process, the resulting colored gelatin exhibits acceptable machineability characteristics and disintegration. As an example, the colored gelatin produced by this process has a viscosity of less than approximately 10,000 cP at about 60 ~C. Additionally, the present invention is a gelatin-based formulation made from the above-described process. The gelatin-based formulation includes gelatin, lake pigment(s), and a sufficient amount of fatty acid to prevent cross-linking between and the cations released from the lake pigment(s). Further, the present invention includes a dosage form that includes the described gelatin-based formulation as the sheath material. The dosage form may encapsulate a liquid, suspension, semi-solid, or solid pharmaceutical, nutritional, herbal, or personal care product, or combination thereof.

L'invention concerne un procédé permettant de colorer des formulations à base de gélatine, qui consiste à ajouter un acide gras saturé à une formulation à base de gélatine ainsi qu'un pigment laque, ledit acide gras saturé étant ajouté en quantité telle qu'il empêche la réticulation de la formulation à base de gélatine et des cations d'aluminium libérés par ledit pigment laque. Cette quantité est, de préférence, d'environ 10 % à 300 en poids du contenu du pigment laque ajouté. Dans ce procédé, la gélatine colorée résultante possède des caractéristiques d'aptitude à l'usinage et de désintégration acceptables. La gélatine colorée produite au moyen de ce procédé possède, par exemple, une viscosité approximativement inférieure à 10,000 cP à environ 60 ·C. L'invention concerne également une formulation à base de gélatine préparée à partir du procédé précité. Une formulation à base de gélatine comprend de la gélatine, un ou des pigment(s) laque, et une quantité suffisante d'acide gras permettant d'empêcher la réticulation entre ladite gélatine et les cations libérés par le ou les pigment(s) laque. L'invention concerne enfin une forme de dosage comprenant la formulation à base de gélatine décrite utilisée comme matériau d'enveloppe. Cette forme de dosage peut encapsuler un liquide, une suspension, un semi-solide, ou un produit pharmaceutique solide, nutritionnel, d'origine végétale ou de soin personnel, ou une combinaison de ceux-ci.

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