Combination

Details Combination Combination

A - Human Necessities

61

K

A61K 31/4045 (2006.01) A61K 31/53 (2006.01) A61K 45/06 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2670741

The invention relates to a combination which comprises : (a) a HDAI; and (b) an anti-metabolite, for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of proliferative diseases, more specifically MDS or AML. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating MDS or AML, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.

L'invention concerne une combinaison qui comprend : (a) un HDAI; et (b) un antimétabolite, pour un usage simultané, concurrent, séparé ou séquentiel, en particulier pour un usage dans le traitement de maladies prolifératives, plus particulièrement le MDS (Syndrome Myélodysplasique) ou l'AML (Leucémie Myéloïde Aiguë). L'invention concerne ainsi des compositions pharmaceutiques, comprenant une telle combinaison, et un procédé de traitement du MDS et de l'AML chez les mammifères, en particulier chez l'homme, avec une telle combinaison. La présente invention concerne en outre un conditionnement commercial ou un produit comprenant une telle combinaison.

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