Combination analgesic employing opioid and neutral antagonist

Details Combination analgesic employing opioid and neutral antagonist Combination analgesic employing opioid and neutral antagonist

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 45/06 (2006.01) A61P 25/04 (2006.01) A61P 25/36 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2702680

A non-addictive analgesic co-formulation comprising an opioid agonist in an amount sufficient to confer analgesia in a mammalian subject and a neutral opioid antagonist in an amount sufficient to inhibit peripheral effects, and insufficient to block substantial central effects, of the opioid agonist in the subject. Such formulations, and methods of using same, may also deter diversion, inhibit peripheral effects, and reduce addiction liability.

La présente invention concerne une co-formulation analgésique non-toxicomanogène comprenant les éléments suivants : un agoniste opioïde, en quantité suffisante pour provoquer une analgésie chez un sujet mammifère; et un antagoniste opioïde neutre, en quantité suffisante pour inhiber les effets périphériques de l'agoniste opioïde chez le sujet et en quantité insuffisante pour bloquer les effets centraux substantiels dudit agoniste. De telles formulations et des procédés utilisant celles-ci peuvent également empêcher la diversion, inhiber les effets périphériques et réduire les risques de dépendance.

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