Combination anticancer therapy and pharmaceutical...

A - Human Necessities – 61 – K

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Details

A61K 31/7024 (2006.01) A61K 31/7016 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 31/7052 (2006.01)

Patent

CA 2587019

This invention relates to anticancer therapy and more precisely to the immunological control of cancer. Specifically this invention relates to pharmaceutical compositions incorporating as the active ingredient at least one immuno-stimulating agent with charged or central groups of general formula (I) wherein X, Y, A, B, RI and R2 are as defined in the specification together with a radiotherapy method suitable to fight cancer or together with a known antineoplastic chemotherapeutic agent selected from the group consisting of alkylating agents, anti-metabolic agents, agents acting on tubules and tyrosine Kinase inhibitors in conjunction or admixture with an inert non toxic pharmaceutically acceptable diluent or carrier. This invention also relates to the salts of a compound of general formula (I) with a mineral or organic base, namely a pharmaceutically -acceptable base. Use for treating cancer conditions within a single container or disposed within distinct containers.

L'invention concerne une thérapie anticancéreuse et plus précisément la maîtrise immunologique du cancer. Plus spécifiquement, l'invention concerne des compositions pharmaceutiques comprenant en tant qu'ingrédient actif au moins un agent immunostimulant avec des groupes centraux ou chargés de formule générale (I), dans laquelle X, Y, A, B, R1 et R2 sont tels que définis dans les spécifications, avec une méthode de radiothérapie adaptée à la lutte contre le cancer ou avec un agent chimiothérapeutique antinéoplasique connu choisi dans le groupe comprenant des agents alcoylants, des agents anti-métaboliques, des agents agissants sur des tubules ou sur des inhibiteurs de tyrosine-kinase en conjonction ou mélange avec un diluant ou support pharmaceutiquement acceptable inerte non toxique. L'invention concerne également les sels d'un composé de formule générale (I) avec une base minérale ou organique, plus spécifiquement une base pharmaceutiquement acceptable. L'invention concerne encore l'utilisation de ces compositions pour traiter des états cancéreux dans un contenant unique ou dans des contenants distincts.

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