A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/21 (2006.01) C07K 14/16 (2006.01)
Patent
CA 2585672
The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.
L'invention concernes des méthodes, des polypeptides et des polynucléotides codant des polypeptides immunogènes du VIH identiques ou analogues, issus des mêmes souches ou de souches différentes à l'intérieur d'un sous-type du VIH et/ou de sous-types différents. L'invention concerne également les utilisations de ces polynucléotides et polypeptides dans des approches combinatoires destinées à produire des réponses immunitaires. Les approches combinatoires selon l'invention comprennent des réponses immunitaires étendues et puissantes contre diverses souches du VIH provenant de souches multiples à l'intérieur d'un sous-type donné, et contre différents sous-types. L'invention concerne encore des préparations de compositions destinées à produire des réponses immunitaires, ainsi que des méthodes d'utilisation de ces compositions.
Barnett Susan W.
Gomez-Roman Victor Raul
Robert-Guroff Marjorie
Srivastava Indresh K.
Borden Ladner Gervais Llp
Novartis Vaccines And Diagnostics Inc.
Novartis Vaccines And Diagnostics Inc.
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
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