A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/21 (2006.01) A61K 31/7088 (2006.01)
Patent
CA 2539021
The present invention relates to methods, polynucleotides, and polypeptides encoding immunogenic HIV polypeptides derived from different strains within an HIV subtype and/or immunogenic HIV polypeptides from different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are described. The combination approaches described herein have been shown to induce broad and potent neutralizing activity against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.
L'invention concerne des procédés, des polynucléotides et des polypeptides codant des polypeptides immunogènes du VIH dérivés de différentes souches dans un sous-type du VIH et/ou des polypeptides immunogènes du VIH de différents sous-types. L'invention concerne des utilisations des polynucléotides et des polypeptides dans approches combinées pour produire des réponses immunitaires. Ces approches combinées induisent une activité de neutralisation large et puissante contre diverses souches du VIH provenant de multiples souches dans un sous-type données et contre divers sous-types. L'invention concerne enfin des formulations de compositions pour produire des réponses immunitaires ainsi que des procédés d'utilisation de ces compositions.
Barnett Susan W.
Gomez-Roman Victor Raul
Lian Ying
Peng Bo
Robert-Guroff Marjorie
Borden Ladner Gervais Llp
Chiron Corporation
The Government Of The United States Of America As Represented By National Institut
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