Combination cancer immunotherapy with co-stimulatory molecules

Details Combination cancer immunotherapy with co-stimulatory molecules Combination cancer immunotherapy with co-stimulatory molecules

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2585776

Provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer by administering an effective amount of a soluble form of a co- stimulatory molecule from an antigen presenting cell and by reducing the activity of immunoregulatory T cells in the individual. Methods of reduction in the activity of immunoregulatory T cells involve removing them ex vivo or depleting or inactivating them in vivo.Also provided are cancer therapeutic compositions comprising a soluble form of a co-stimulatory molecule from an antigen presenting cell and an antibody specific for an intracellular antigen.

L'invention concerne des méthodes permettant de réduire la taille d'une tumeur ou d'inhiber la croissance de cellules cancéreuses chez un individu ou d'inhiber le développement d'un cancer métastatique, consistant à administrer une dose utile d'une préparation soluble renfermant une molécule co-stimulatrice d'une cellule présentant antigène et à réduire l'activité de lymphocytes T immunorégulateurs chez l'individu. Les méthode de réduction de l'activité des lymphocytes T immunorégulateurs consistent à retirer ces derniers ex vivo ou à en réduire le nombre ou à les désactiver in vivo. L'invention concerne également des compositions thérapeutiques anticancéreuses comprenant une préparation soluble renfermant une molécule co-stimulatrice d'une cellule présentant antigène et un anticorps spécifique d'un antigène intracellulaire.

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