Combination comprising...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/506 (2006.01) A61K 31/337 (2006.01) A61K 31/4196 (2006.01) A61K 31/675 (2006.01) A61K 31/704 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2444867

A method of treating a warm-blooded animal, especially a human, having a proliferative disease or acute or chronic transplant rejection comprising administering to the animal a combination which comprises (a) N-{5-[4-(4- methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2- pyrimidine-amine and (b) a chemotherapeutic agent selected from antineoplastic agents, especially as defined herein, and agents effective in treating acute or chronic transplant rejection; a combination comprising (a) and (b) as defined above and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease.

L'invention concerne une méthode de traitement d'un animal à sang chaud, notamment un être humain, atteint d'une maladie proliférative ou de rejet aigu ou chronique du greffon. Cette méthode consiste à administrer à un animal une combinaison renfermant (a) N-{5-[4-(4-méthyl-piperazino-méthyl)-benzoylamido]-2-méthylphényl}-4-(3-pyridyl)-2-pyrimidine-amine et (b) un agent chimiothérapeutique sélectionné parmi des agents antinéoplastiques, notamment des agents tels que définis dans la description, et des agents efficaces dans le traitement de rejet aigu ou chronique du greffon; une combinaison renfermant (a) et (b) tels que définis ci-dessus et éventuellement au moins un excipient acceptable sur le plan pharmaceutique destiné à une utilisation simultanée, distincte ou séquentielle, notamment pour le retard de la progression ou le traitement d'une maladie proliférative, notamment une maladie impliquant une tumeur solide.

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