A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/35 (2006.01) A61K 31/4152 (2006.01) A61K 31/53 (2006.01) A61K 31/55 (2006.01) A61K 38/13 (2006.01) A61P 25/06 (2006.01) A61P 25/08 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01)
Patent
CA 2446160
The invention relates to a combination which comprises a P-glycoprotein (P-gp) inhibitor and an antiepileptic drug selected from phenytoin (5,5-diphenyl-2,4- imidazolidinedione), carbamazepine, lamotrigine, gabapentin, oxcarbazepin, valproic acid, and topiramate, and its use for the prevention, delay of progression or treatment of diseases, in particular epilepsy, especially epilepsy which is resistant to antiepileptic drugs.
L'invention concerne une combinaison qui comprend un inhibiteur de la P-glycoprotéine (P-gp) et un médicament anti-épileptique sélectionné parmi la phénytoïne (5,5-diphényl-2,4-imidazolidinédione), la carbamazépine, la lamotrigine, la gabapentine, l'oxcarbazépine, l'acide valproïque, et le topiramate. L'invention concerne également l'utilisation de cette combinaison pour prévenir, retarder la progression ou traiter des maladies, telles que l'épilepsie et, plus particulièrement, l'épilepsie résistante aux médicaments anti-épileptiques.
Loescher Wolfgang
Potschka Heidrun
Schmutz Markus
Fetherstonhaugh & Co.
Loescher Wolfgang
Novartis Ag
Potschka Heidrun
LandOfFree
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