Combination comprising an agent decreasing vegf activity and...

A - Human Necessities – 61 – K

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Details

A61K 31/519 (2006.01) A61K 31/337 (2006.01) A61K 31/404 (2006.01) A61K 31/502 (2006.01) A61K 31/5377 (2006.01) A61K 31/7068 (2006.01) A61P 35/00 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2427184

The invention relates to a combination which comprises a first active ingredient which is a vasculostatic compound and a second active ingredient which decreases the activity of the epidermal growth factor (EGF), in particular, for the delay of progression or treatment of a disease associated with deregulated angiogenesis, especially a proliferative disease; a pharmaceutical composition comprising such a combination; a commercial package comprising such a combination as a combined preparation; and to a method of treatment of a warm-blooded animal, especially a human.

L'invention concerne une combinaison qui comprend un premier ingrédient actif étant un composé vasculostatique et un second ingrédient actif qui diminue l'activité du facteur de croissance de l'épiderme (EGF). Cette combinaison permet plus spécifiquement le retard de la progression ou le traitement d'une maladie associée à une angiogénèse déréglée, spécialement une maladie proliférative. L'invention concerne également une composition pharmaceutique comprenant une telle combinaison, un emballage commercial comprenant une telle combinaison en tant que préparation combinée, et un procédé de traitement d'animaux à sang chaud, plus spécialement d'humains.

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