Combination dosing regimen for erythropoietin

A - Human Necessities – 61 – K

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Details

A61K 38/18 (2006.01) A61P 7/06 (2006.01)

Patent

CA 2561222

The present invention provides a combination dosing regimen for erythropoietin (EPO). More particularly, the present dosing regimen includes administration of at least a first dosing segment comprising a first exposure to EPO capable of stimulating the production of reticulocytes followed by a second exposure to EPO capable of sustaining the maturation of the reticulocytes into neocytes, and ultimately, red blood cells. Advantageously, the dosing segment may be cycled or repeated, any number of times and according to any desired time scheme, in order to provide or maintain any desired total red blood cell count and/or hemoglobin concentration. Methods of treatment employing the combination dosing regimen, as well as kits are also provided.

La présente invention concerne une combinaison de dosages d'erythropoïétine (EPO). Plus particulièrement, ce dosage comprend l'administration d'au moins une première partie de dosage comprenant une première exposition à l'EPO capable de stimuler la production de réticulocytes, suivie par une seconde exposition à l'EPO capable de soutenir la maturation de ces réticulocytes en néocytes et, enfin, n'importe quel nombre de fois et conformément à n'importe quel schéma temporel souhaité, afin de fournir ou maintenir n'importe quelle numération de globules rouges et/ou concentration d'hémoglobine. Cette invention concerne aussi des techniques de traitement utilisant cette combinaison de dosages ainsi que des kits.

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