Combination drug therapy for treating hypertension

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/40 (2006.01) A61K 31/13 (2006.01) A61K 31/54 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2521014

Disclosed are compositions and methods for treating, preventing, and ameliorating hypertension, especially in patients with coronary artery disease, patients at risk for strokes, patients with renal disease, and patients with diabetes or at risk for diabetes. The compositions and methods relate to a combination therapy using three classes of anti-hypertension drugs, including calcium antagonists, angiotensin-converting-enzyme inhibitors, and diuretics. The preferred drugs in the compositions and methods are verapamil, trandolapril, and hydrochlorothiazide.

L'invention concerne des compositions et des méthodes de traitement, de prévention et de réduction de l'hypertension, en particulier chez les patients atteints de coronaropathie, les patients présentant un risque d'accident vasculaire cérébral, les patients atteints de néphropathie et les patients atteints de diabète ou à risque. Les compositions et méthodes selon l'invention concernent un traitement par association mettant en oeuvre trois classes de médicaments contre l'hypertension, notamment des antagonistes de calcium, des inhibiteurs de l'enzyme de conversion de l'angiotensine et des diurétiques. Les médicaments préférés desdites compositions et méthodes sont le vérapamil, le trandolapril et l'hydrochlorothiazide.

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