Combination effective for the treatment of impotence

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/519 (2006.01) A61K 31/18 (2006.01) A61K 31/454 (2006.01) A61K 31/4725 (2006.01) A61K 31/495 (2006.01) A61K 31/517 (2006.01) A61P 15/10 (2006.01)

Patent

CA 2314993

The invention relates to the treatment of erectile dysfunction with a combination of (1) a compound selected from .alpha.-adrenergic receptor antagonists, and (2) a compound selected from agents which elevate cGMP levels. Sildenafil or a pharmaceutically acceptable salt thereof is preferred as the cGMP PDE elevator. Also included are compositions and kits comprising such impotence treating compounds.

L'invention concerne le traitement de la dysérection au moyen d'une composition renfermant en combinaison (1) un composé choisi parmi les antagonistes vis-à-vis des récepteurs alpha-adrénergiques, et (2) un composé choisi parmi les agents qui élèvent les niveaux de l'acide guanylique cyclique (GMP cyclique). De préférence, on utilise le sildénafil ou un sel pharmaceutiquement acceptable de cet élément comme agent élévateur de GMP cyclique phosphodiestérase. L'invention concerne également des compositions et des kits renfermant lesdits composés de traitement de l'impuissance.

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