C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/56 (2006.01) A61K 31/27 (2006.01) A61K 31/395 (2006.01) C07C 271/40 (2006.01) C07C 271/44 (2006.01) C07D 207/33 (2006.01) C07D 209/58 (2006.01) C07D 231/06 (2006.01) C07D 261/08 (2006.01) C07D 263/32 (2006.01) C07D 307/38 (2006.01) C07D 401/04 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2661085
Pharmacological inhibition of fatty acid amide hydrolase (FTVAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit FAAH activity and further provide an analgesic, anti-inflammatory, or anti-pyretic agent. Described herein is a process for the preparation of esters of alkylcarbamic acid compounds, compositions that include them, and methods of use thereof.
La présente invention concerne l'inhibition pharmacologique de l'activité amide d'acide gras hydrolase (FTVAH) qui conduit à des niveaux accrus d'amides d'acide gras. L'invention concerne des esters d'acides alkylcarbamiques qui sont des inhibiteurs de l'activité de la FAAH. Les composés selon l'invention inhibent l'activité de la FAAH et produisent en outre un agent analgésique, anti-inflammatoire, ou anti-pyrétique. L'invention concerne un procédé qui permet la préparation d'esters de composés d'acide alkylcarbamique, des compositions qui les contiennent, et des procédés permettant leur utilisation.
Fetherstonhaugh & Co.
N.v. Organon
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