A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/164
A61K 9/22 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01)
Patent
CA 1218305
ABSTRACT OF THE DISCLOSURE A pharmaceutical oral controlled release multiple-unit dosage form is provided, which contains a multiplicity of individual coated units, each unit containing an active substance coated with a water-insoluble, but water-diffusable controlled release coating, each unit additionally comprising articles of active substance adhered to the surface of the controlled release coating in a substantially uniform layer, the particles being at least one power of 10 smaller than the coated units. Suitably the coated units have a mean size of between about 0.1 and 1.5 mm. They are prepared by a mixing process performed in the presence of an anti-adhesive which counteracts undesired electrostatic charges in carrier materials such as talc or colloidal silicon dioxide. The active substance which is subject to controlled release may be potassium chloride, and the active substance of the small particles may be a diuretic.
434484
Roswall Stig
Thorhus Lene B.
Benzon Pharma A/s
Mccarthy Tetrault Llp
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