A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 31/19 (2006.01)
Patent
CA 2535889
The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, in a first treatment procedure, and a second amount of an anti-cancer agent in a second treatment procedure. The first and second amounts together comprise a therapeutically effective amount. The effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.
La présente invention concerne une méthode destinée à traiter le cancer chez un sujet nécessitant un tel traitement, et consistant à administrer à ce sujet une première dose d'un inhibiteur d'histone désacétylase (HDAC), ou un sel ou un hydrate pharmaceutiquement acceptable dudit composé, dans une première procédure de traitement, et une seconde dose d'un agent anticancéreux dans une seconde procédure de traitement. Lesdites première et seconde doses constituent ensemble une dose thérapeutiquement efficace. L'effet de l'inhibiteur de HDAC et de l'agent anticancéreux peut être additif ou synergique.
Bacopoulos Nicholas G.
Chiao Judy H.
Marks Paul A.
Miller Thomas A.
Paradise Carolyn M.
Aton Pharma Inc.
Merck Hdac Research Llc
Ridout & Maybee Llp
Sloan-Kettering Institute For Cancer Research
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