C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2457485
A class of immunostimulatory nucleic acids having at least two functionally and structurally defined domains is provided. This class of combination motif immunostimulatory nucleic acids activates an immune response and is useful for treating a variety of immune realted disorders such as cancer, infectious disease, and allergic disorders. The nucleic acids also stimulate activation of natural killer cells and production of type 1 interferon.
L'invention concerne une classe d'acides nucléiques immunostimulateurs comportant au moins deux domaines définis du point de vue fonctionnel et structural. Cette classe d'acides nucléiques immunostimulateurs à motif combiné active une réaction immunitaire et est utile dans le traitement de divers troubles d'ordre immunitaire tels que le cancer, les maladies infectieuses et les affections allergiques. Ces acides nucléiques stimulent aussi l'activation de cellules tueuses naturelles et la production d'interférons de type 1.
Krieg Arthur M.
Uhlmann Eugen
Vollmer Jorg
Coley Pharmaceutical Gmbh
Smart & Biggar
University Of Iowa Research Foundation
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