Combination of a)...

Details Combination of a)... Combination of a)...

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/19 (2006.01) A61K 31/404 (2006.01) A61K 31/4406 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2498210

The invention pertains to a combination of a histone deacetylase inhibitor and N-~5-~4-(4methyl-piperazino-methyl)-benzoylamido~-2-methylphenyl}-4-(3- pyridyl)-2-pyrimidine or a pharmaceutically acceptable salt thereof for simultaneous, separate or sequential use for the treatment of leukemia and especially N-15-~4-(4-methyl-piperazino-methyl)-benzoylamido~-2methylphenyl)-4- (3-pyridyl)-2-pyrimidine-resistant leukemia.

L'invention concerne une combinaison d'un inhibiteur de l'histone déacétylase et de N-Ý5-Ý4-(4méthyl-pipérazino-méthyl)-benzoylamido¨-2-méthylphényl}-4-(3-pyridyl)-2-pyrimidine ou d'un sel pharmaceutiquement acceptable de ce dernier en vue de son utilisation simultanée, séparée ou ou séquentielle dans le traitement de la leucémie, en particulier la leucémie résistant à N-Ý5-Ý4-(4méthyl-pipérazino-méthyl)-benzoylamido¨-2-méthylphényl}-4-(3-pyridyl)-2-pyrimidine.

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